Detailansicht Stifte


Kötter S, Unger A, Hamdani N, Lang P, Vorgerd M, Nagel-Steger L, Linke WA. J Cell Biol. 204(2):187-202  (2014)


Krüger M, Kötter S. Titin – sensibler Riese der Muskelzellen. Biospektrum Ausgabe 4/2013:360-362 (2013)

Kötter S, Gout L, von Frieling-Salewsky M, Müller AE, Helling S, Marcus K, dos Remedios C, Linke WA, Krüger M.  Differential changes in titin domain phosphorylation increase myofilament stiffness in failing human hearts. Cardiovasc Res. 99(4):648-56 (2013)


Krüger M. Too light to be essential? Insights from FHC-related mutations in essential myosin light chains. Cardiovasc Res., 93(3):381-2 (2012)

Donlin LT, Andresen C, Just S, Rudensky E, Pappas CT, Kruger M, Jacobs EY, Unger A, Zieseniss A, Dobenecker MW, Voelkel T, Chait BT, Gregorio CC, Rottbauer W, Tarakhovsky A and Linke WA. Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization. Genes & Dev. 26(2):114-9 (2012)


Krüger M, Linke WA. The giant protein titin: a regulatory node that integrates myocyte signaling pathways. J Biol Chem. 286(12):9905-9912 (2011)

Bishu K, Hamdani N, Mohammed SF, Kruger M, Ohtani T, Ogut O, Brozovich FV, Burnett JC Jr, Linke WA, Redfield MM.Sildenafil and B-Type Natriuretic Peptide Acutely Phosphorylate Titin and Improve Diastolic Distensibility In Vivo. Circulation. 124(25):2882-91 (2011)


Linke WA and Krüger M. The giant protein titin as an integrator of myocyte signaling pathways. Physiology 25(3):186-98 (2010)

Toischer K, Rokita AG, Unsöld B, Zhu W, Kararigas G, Sossalla S, Reuter SP, Becker A, Teucher N, Seidler T, Grebe C, Preuss L, Gupta SN, Schmidt K, Lehnart SE, Krüger M, Linke WA, Backs J, Regitz-Zagrosek V, Schäfer K, Field LJ, Maier LS, Hasenfuss G. Differential cardiac remodeling in preload versus afterload. Circulation 122(10):993-1003 (2010)

Krüger M, Babicz K, von Frieling-Salewsky M, Linke WA. Insulin signaling regulates cardiac titin-isoform composition in heart development and diabetic cardiomyopathy. J Mol Cell Cardiol. 48: 910–916 (2010)


Krüger M, Kötter S, Grützner A, Lang P, AndresenC, Butt E, dos Remedios CG, Redfield MM, Linke WA. Protein Kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs. Circ Res. 104: 87-94 (2009)

Krüger M and Linke WA. Titin-based mechanical signalling in normal and failing myocardium. J Mol Cell Cardiol. 46; 490-498 (2009)


Shapiro BP, Owan TE, Mohammed S, Krüger M, Linke WA, Burnett JC Jr, Redfield MM. Mineralocorticoid signaling in transition to heart failure with normal ejection fraction. Hypertension. 51(2):289-95 (2008)

Krüger M, Sachse C, Klede S, Eschenhagen T, Zimmermann WH, Linke WA. Thyroid hormone regulates developmental titin isoform transitions via the PI3K/AKT pathway. Circ Res. 102(4):439-47 (2008)


Shapiro BP, Lam CSP, Patel JB, Mohammed SF, Krüger M, Meyer DM, Linke WA, Redfield MM. Acute and chronic ventricular-arterial coupling in systole and diastole: insights from an elderly hypertensive canine model. Hypertension 50 (3): 503-11(2007)


Leake MC, Grützner A, Krüger M, and Linke WA. Mechanical properties of cardiac titin’s N2B region by single molecule atomic force spectroscopy. J Struct Biol 155: 263-272 (2006)

Olsson MC, Krüger M, Meyer LH, Ahnlund L, GransbertL, Linke WA, and Larsson L. Fibre type specific increase in passive muscle tension in spinal cord injured subjects with spasticity. J Physiol. 577: 339-352 (2006)

Krüger M, Kohl T, Linke WA. Developmental changes in passive stiffness and myofilament Ca2+-sensitivity due to titin and troponin-I isoform switching are not critically triggered by birth. Am J Physiol Heart Circ Physiol 291: 496-506 (2006)

Krüger M and Linke WA. Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension. J Muscle Res Cell Motil 27: 435-444 (2006)


Krüger M, Zittrich S, Redwood C, Blaudeck N, James J, Robbins J, Pfitzer G, Stehle R. Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction-relaxation cycle in isolated cardiac myofibrils. J Physiol 564: 347-357 (2005)

Prado LG, Makarenko I, Andresen C, Krüger M, Opitz CA and Linke WA. Isoform diversity of giant proteins in relation to passive and active contractile properties of rabbit skeletal muscles. J Gen Physiol 126: 461-80 (2005)

Vor 2005:

Krüger M, Pfitzer G, Stehle R. Expression and purification of human cardiac troponin subunits and their functional incorporation into isolated cardiac mouse myofibrils. J Chromatogr B Analyt Technol Biomed Life Sci 786(1-2): 287-96 (2003).

Desimone M, Krüger M, Wessel T, Wehofsky M, Hoffmann R, Wagner E. Purification and characterization of an aminopeptidase from the chloroplast stroma of barley leaves by chromatographic and electrophoretic methods. J. Chromatogr B Biomed Sci Appl 737 (1-2): 285-93 (2000)

Stehle R, Krüger M, Pfitzer G. Force kinetics and individual sarcomere dynamics in cardiac myofibrils after rapid Ca2+ changes. Biophysical Journal 83: 2152-2161 (2002)

Stehle R, Krüger M, Brixius K, Schwinger RHG, Pfitzer G. 2001. Isometric force kinetics upon rapid activation and relaxation of mammalian and human heart muscle studied on the subcellular myofibrillar level. Basic Res Cardiol 97: Suppl.1, I/127-I/135 (2002)

Stehle R, Krüger M, Pfitzer G. Does cross-bridge activation determine the time course of myofibrillar relaxation? Adv Exp Med Bio 538: 469-79 (2003)

Siedner S, Krüger M, Schroeter M, Metzler D, Roell W, Fleischmann BK, Hescheler J, Pfitzer G, Stehle R. Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart. J Physiol 54: 493-505 (2003)